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users usually relish flavor from the initial puff to the final one

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(3) The pyridine ring is further opened to produce 2,6-dihydroxy pseudooxynicotine (2,6-DPHON) [53]

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Together, abnormal smoking-related DNAm in the aryl hydrocarbon receptor signaling pathway may induce more DNA adduct formation that leads to miscoding of the sequence of DNA (see Fig