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On histopathological examination of oral leukoplakia, hyperkeratinisation is always present, which is responsible for the white appearance of the patch

In particular, some substances present in traditional cigarette smoke, such as polycyclic aromatic hydrocarbons (PAHs), acetone, pyridine, heavy metals, benzene, carbon monoxide, nicotine, can influence absorption, distribution, metabolism and elimination of a drug and it can alter the response of the cellular receptors on which they act, resulting in changes of the effectiveness and safety of pharmacological treatments

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In the case of the Marauders, whose diet consisted of 80% K-rations, severe weight loss (an average of 35 pounds or 16 kilograms per man) and vitamin deficiency were noted, which may have also contributed to a decline in resistance to various tropical diseases