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Abbreviations COPD: Chronic obstructive pulmonary disease CC10: Club cell 10 kDa secretory protein CS: Cigarette smoking WT: Wild-type CSE: Cigarette smoke extract mIHC: Multiplexed immunohistochemistry ELISA: Enzyme-linked immunosorbent assay BALF: Bronchoalveolar lavage fluid IF: Immunofluorescence SEM: Scanning electron microscopy TEM: Transmission electron microscopy NC: Negative control MAST: Mean alveolar septal thickness WBC: White blood cell References Agust A, Celli BR, Criner GJ, et al

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Ding YS, Blount BC, Valentin-Blasini L, et al

Because of the advantages of alternate day therapy, it may be desirable to try patients on this form of therapy who have been on daily corticoids for long periods of time (e.g., patients with rheumatoid arthritis)