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Smokeless tobacco, such as loose leaf pouches, plugs or snuff, are chewed or held in place, allowing the nicotine to get into the bloodstream through the mouth

We will examine two such brands in more detail

product similarity - Businesses in an oligopoly offer products or services that are nearly identical or very similar

Russell and co-workers proposed that powdered nasal snuff might serve as an effective substitute for cigarettes because it delivers nicotine effectively without the risks of tobacco combustion [4]

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Elevated levels of 8-oxodG and/or significant induction of G:CT:A transversion as well as G:CA:T transition and G:CC:G transversion mutations have been reported in numerous studies investigating the effects of oxidative stress associated with tobacco smoke exposure in vitro or in vivo [12, 23, 77, 142, 156159]