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If you are a pipe smoker you have dealt with stale tobacco at one time or another

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Hence, indoor smoking should be avoided

38,42 Distinguishing between vaping and smoking may be obvious for some but not for others, for example, children 43 it may be difficult to police and it may be too early for research to establish if, or how, vaping changes the perceptions of smoking

Compared with traditional meta-analysis using linear mixed effect models, MR-BRT relaxes the assumption of a log(linear) relationship between exposure and risk, incorporates between-study heterogeneity into the uncertainty of risk estimates, handles estimates reported across different exposure categories, automatically identifies and trims outliers, and systematically tests and adjusts for bias due to study designs and characteristics