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, is a condition defined as the misuse of tobacco substances and where the individuals are heavily dependent on nicotine, which is found in tobacco

International Journal of Environmental Research and Public Health: American Lung Association: The Centers for Disease Control and Prevention: National Association of Secondary School Principals: The Centers for Disease Control and Prevention, Notes from the Field: E-CigaretteAssociated Cases Reported to Poison Centers United States, April 1, 2022March 31, 2023 CDC, MMWR, June 2023

This hypothesized difference, the smallest detectable among all the primary endpoint comparisons, served as the basis for sample size calculation

Int J Oral Maxillofac Implants 1993

IQOS HEETS will last for approximately 6 minutes, or 14 puffs, which is a similar duration to that of a cigarette