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Nevertheless, complement activation in the pathogenesis of cardiovascular disease is well described, from the earliest signs of endothelial dysfunction, followed by progression to the formation of atherosclerotic plaques and vascular thrombus, with accompanied proinflammatory and procoagulant changes [63, 64]

8 A 2017 survey of Australian secondary students found that 21.6% of Aboriginal and Torres Strait Islander students reported ever use of e-cigarettes, which was significantly higher than non-Indigenous students (13.5%)

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