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Matschke J, Riffkin H, Klein D, Handrick R, Ludemann L, Metzen E, et al

Assuming that dried tobacco contains between 0.6 and 2.9 percent nicotine which is a common estimate*1 a single cigarette contains approximately 4 to 20 mg of nicotine

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Certain structures of the central nervous system will transform to accommodate the nicotine as a primary source of releasing dopamine, yet at the same time, the effects of nicotine will lessen, which creates the need to consume higher doses to get the same dopaminergic effects

The best way to prevent lung disease is to stop smoking