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Tobacco Products are a Global Pediatric concern Tobacco and nicotine product use, along with exposure to second-hand smoke, are becoming increasingly serious and have posed an ever-growing global pediatric threat Tobacco use among children and adolescents is associated with an increased probability of tobacco addiction, reduced lung function, impaired lung growth during childhood and adolescence, increased incidence of asthma, subclinical atherosclerosis, mental health disorders (anxiety, depression), and developmental disorders (ADHD and behavioral disorders) in adolescents

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To reduce the effect of bias, we adjusted observations that did not account for more than five confounders, including age and sex, because they were the significant bias covariates identified by the bias covariate selection algorithm 29 (Supplementary Table 7)

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Reynolds Tobacco, British American Tobacco, Liggett Group, Brown & Williamson and Lorillard Tobacco

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