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First, the pharmacology of nicotine, the primary psychoactive component of tobacco cigarettes, will be discussed including its role in neurotransmission, drug reward pathways, and nicotine dependence [ Pharmacology Cigarette smoke is composed of a complex array of chemical constituents including products such as carboxylic acids, phenols, water, humectants, terpenoids, paraffin waxes, tobacco-specific nitrosamines, (TSNAs), and catechols [ and subunits ( 17, 910

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Furthermore, studies using diet-induced models of MASLD have shown that e-cigarette exposure exacerbates preexisting liver injury, worsening steatohepatitis through amplified oxidative stress, mitochondrial dysfunction, and inflammatory responses [134]