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Tobacco Control 11(Suppl 1):i102i109

Preclinical and clinical data suggests that although sociocultural influences significantly affect smoking adolescence, adolescent sensitivity to nicotine has strong neurobiological underpinnings ( Adolescence is a sensitive period for maturation of brain circuits that regulate cognition and emotion, with resulting vulnerability to the effects of nicotine and tobacco ( Adolescence is marked by major physical changes in the body, however the hallmark of this period is a major reorganization of forebrain circuitry ( Structural Changes in the Adolescent Brain The structural changes in the adolescent brain include prolonged reorganization of gray matter, white matter, and associated neurochemical systems

Swan et al

Relationship of ADHD, depression, and non-tobacco substance use disorders to nicotine dependence in substance-dependent delinquents

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