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Sinha-Hikim, [email protected] Specialty section: This article was submitted to Cellular Endocrinology, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Since the highest tar-and-nicotine content is to be found, generally speaking, in the best-selling brands of cigarettes, a good argument can be made for federal health regulations that would require systematic further reductions of the tar-and-nicotine content of all cigarettes over, say, a ten-year period

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