Federal Cigarette Labeling and Advertising Act of 1965 Required package warning labelCaution: Cigarette Smoking May Be Hazardous to Your Health (other health warnings prohibited) Required no labels on cigarette advertisements (in fact, implemented a three-year prohibition of any such labels) Required FTC to report to Congress annually on the effectiveness of cigarette labeling, current cigarette advertising and promotion practices, and to make recommendations for legislation Required Department of Health, Education, and Welfare (DHEW) to report annually to Congress on the health consequences of smoking More on the Federal Cigarette Labeling and Advertising Act of 1965 Public Health Cigarette Smoking Act of 1969 Required package warning label Warning: The Surgeon General Has Determined that Cigarette Smoking Is Dangerous to Your Health (other health warnings prohibited) Temporarily preempted FTC requirement of health labels on advertisements Prohibited cigarette advertising on television and radio (authority to Department of Justice [DOJ]) Prevents states or localities from regulating or prohibiting cigarette advertising or promotion for health-related reasons Controlled Substances Act of 1970 To prevent the abuse of drugs, narcotics, and other addictive substances Specifically excludes tobacco from the definition of a controlled substance Consumer Product Safety Act of 1972 Transferred authority from the FDA to regulate hazardous substances as designated by the Federal Hazardous Substances Labeling Act (FHSA) to the Consumer Product Safety Commission (CPSC) The term consumer product does not include tobacco and tobacco products Little Cigar Act of 1973 Bans little cigar advertisements from television and radio (authority to DOJ) 1976 Amendment to the Federal Hazardous Substances Labeling Act of 1960 The term hazardous substance shall not apply to tobacco and tobacco products (passed when the American Public Health Association petitioned CPSC to set a maximum level of 21 mg
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Also, it was reported that activating Nrf2/GCL/GSH antioxidant signaling pathway by quercetin could attenuate toosendanin-induced oxidative stress to prevent hepatotoxicity [58], and Nrf2/GCL/GSH axis could protect mitochondria from methylglyoxal-induced cells [59]
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