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10 The underlying mechanisms likely involve diverse constituents of smoke, including nicotine, oxygen free radicals, and carbon monoxide, which may affect various targets, such as the mucus layer, gut microbiota, immune cells, gastrointestinal motility, and microvasculature

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"When it comes to other substances, smoking has been linked to increased cravings for stimulants and opiates and could trigger a relapse," he warned

The combined exposures create a risk that is many times that of either risk factor alone

Placebo THC was administered each day, except during one of the abstinence phases (days 914), when active THC was given

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