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Palladino and his staff of seven investigators had to move quickly

Hansen, M

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Effect of exacerbations on quality of life in patients with chronic obstructive pulmonary disease: a 2 year follow up study

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Patients are treated with high-dose prednisone and cytotoxic therapy such as cyclophosphamide usually for many months.45 Treatment and/or maintenance with methotrexate, azathioprine, and mycophenolate mofetil mitigates toxicity of prolonged cyclophosphamide use