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This epigenetic reprogramming may underlie the immunosuppressive effects observed in cannabis smokers, as the transition from a Th 1 to a Th 2 response is associated with impaired cytokine production and diminished antimicrobial activity of AMs (75)

[107] Picard concludes that "[t]his could lead to a spiritual interpretation in some individuals." [107] Other clinical conditions [edit] The insular cortex has been suggested to have a role in anxiety disorders, [108] emotion dysregulation, [109] and anorexia nervosa

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