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Tobacco smoke contains nicotine and other chemicals, such as cadmium, that can affect central nervous system structures [69] or stimulate expression of pro-inflammatory molecules resulting in peripheral and central sensitization which can contribute to the development of headache pain [7072]

Secondly, its just so convenient to vape anywhere, anytime, and that ease might lead to higher nicotine intake over time, Ms Lim added

35 If used, bupropion should be started at least one week prior to the patients quit date and continued for at least seven weeks

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