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Normally, these receptors are activated by the neurotransmitter acetylcholine, which is produced at both nerve endings in the brain as well as nerves of the peripheral nervous system (PNS)

showed that the extract from electronic cigarettes (containing different flavours and nicotine quantity) applied to cultured myocardial cells at different dilution, both with or without nicotine, was cytotoxic at different concentrations irrespective of nicotine presence

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