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In 1973, the first study to show association between cigarette smoking and pancreatic cancer in humans was published by Wynder et al (121)

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But if youre looking for a quick January cut before a trip somewhere warm: hit the gym, boil some eggs, and make yourself a Negroni

This involves an interim stage of analysis to allow for a more accurate estimation of the SD as a basis for assessing whether the expected effect size can be feasibly demonstrated (A note on protocol V3.0.pdf)

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The authors added: Studies suggest that smokers typically lose about the same number of healthy years as they do total years of life