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All cancers go through five stages of progression, which are: Stage 0 cancer has stayed in place and has not spread to other tissue Stage 1 cancer has not grown too deep into the tissue and has not spread to other parts of the body Stage 2 cancer has grown to the outer layers of the colon Stage 3 cancer has grown through the colon and reached nearby lymph nodes Stage 4 cancer has reached tissues in other parts of the body There are numerous factors that determine how long it takes to go from one stage to the next, so there is no standard timeline

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Department of Agriculture, October 1943

A European first for the roll your own (RYO) category, and a world first for JTI, Amber Leaf Signature Blend answers a demand from over 70% of existing adult smokers who declare an interest in organically grown tobacco