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[83] Nicotine addiction is a disorder which alters different neural systems such as dopaminergic, glutamatergic, GABAergic, serotoninergic, that take part in reacting to nicotine

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Giving up important occupational, social, and recreational activities because of substance use: An individual with substance addiction tends to give up or reduce their participation in meaningful occupational, social, and recreational activities due to substance use

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