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Sugar shaped the modern world in other awful ways, too, from slavery to the Holocaust

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When neurobiologists compare the limbic system nerve cells of smokers to those of nonsmokers, they find changes in both the number of nicotine receptors and in the levels of RNA used to make the receptors

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We think that while it is clear that different endpoints may yield quite different results, the human MOE for cannabis based on the endpoint psychotropic effects can be seen as general validation of the MOE concept, because the resulting values below 1 are expected as the psychotropic effect is the desired endpoint (and hence the psychotropic threshold dose is exceeded by drug users)