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Scientists are calling for a major effort to make cannabis use less harmful as a rising number of countries look to replace long-standing and outright bans on the drug with more relaxed legislation

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Tobacco contains the addictive substance nicotine

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The concern would be that, for nonsmokers and teens, e-cigs become a gateway to nicotine addiction. In addition, the long-term effects of substances found in vape liquids, like propylene glycol, are still unknown, so until we have more definitive data, caution is the watchword