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The 0.5 mg tablets are to be used for the first 7 days of the treatment

In a CS-exposed mouse model (5 days/week for 46 months), genes associated with the TCA cycle, fatty acid oxidation, and redox regulation were compensatorily upregulated in pulmonary epithelial cells, accompanied by mitochondrial morphological and functional abnormalities including reduced cristae number, enlarged volume, decreased membrane potential, and reduced OCR

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Proliferative responses of lymphoid tissue associated with the lung to T-cell mitogens were unaffected by this exposure, by the relative amounts of T and B cells in lymph node cells associated with the lung or in the spleen, or by macrophage function in the spleen

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