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We screened the first 1000 search results based on our eligibility criteria and compared the included studies with those selected by the KCL review 5

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This draft guidance will increase the number of flavored e-cigarettes that FDA authorizes. Given the importance of preventing youth use of all tobacco products and the strong evidence that flavors increase the appeal and use of e-cigarettes by youth, FDA should not ignore the basic reality that kids are drawn to what flavors are most available to them, particularly since FDA recognizes the underlying risk of flavors to youth We request a timely response that addresses the concerns we have about the new draft guidance, the Senators concluded

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