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doi:10.1016/j.mayocp.2011.10.003

Key to this approach are (i) the use of agreed reference products for comparison, ideally authorized MRTPs, and (ii) bridging methodologies that allow to compare a cMRTP with the reference products based on a limited number of studies (see challenge 4)

While overall youth tobacco and nicotine use is declining, many of those who do use are showing troubling signs of dependence as illegal flavored, high-nicotine products surge, said Kathy Crosby, CEO and President of Truth Initiative

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