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However, in the context of chronic inflammation, pruritogenic mediators and neurotrophic factors can significantly reduce this threshold, rendering sensory fibers hyperexcitable and responsive to otherwise non-pruritic inputs (127)

2017;14:641-651.[PubMed Abstract] - 22.Grebely J, Dalgard O, Conway B, et al

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People may also notice a tingling, itching, or burning feeling a few days before the sores appear

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the building was given a plain colour wash, and the factory could be seen at last as a modern building