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We will then discuss how gestational exposure to nicotine activates or inhibits nAChRs and leads to deleterious changes in neurodevelopment such as decreased brain volume, upregulation of nAChRs, changes in signaling of the hypothalamic-pituitary-axis (HPA), and changes to brain regions such as the prefrontal cortex (PFC), ventral tegmental area (VTA), nucleus accumbens (NA), and caudate

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[DOI] [PubMed] [Google Scholar] 91.Hakim AJ, Grahame R

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This makes it one of the longest-lasting disposable options available, essentially becoming a year-long vaping solution for occasional users