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Smokeless tobacco's digestive effects may result from: Higher nicotine absorption rates than cigarettes Longer duration of use (pouches often remain in place for 30-60 minutes) Additional compounds in tobacco that affect digestive functioning Historically, tobacco leaf preparations have been used for their laxative effects, suggesting this digestive response has been known for centuries

PMID 10883558

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And the Food and Drug Administration even uses the concept as the tagline in its anti-vaping video ads: Teens who vape are more likely to start smoking cigarettes. For now, experts on both sides acknowledge there is no definitive evidence linking e-cigarettes to the decline in youth smoking

doi: 10.1136/gut.2003.025403 131 PanicN