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Older adults and people with pre-existing conditions are deemed 'higher risk,' including individuals with heart disease, lung disease and diabetes

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However, some of the herbs used in these products may have health benefits, while others may have negative health effects if inhaled

Substantive review of a PMTA, for example, includes a multi-disciplinary review of a products engineering, chemistry, toxicology, behavioral and clinical pharmacology, microbiology, individual health impact, and population health impact