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Sustained NRF2 activation probably contributes to persistent antioxidant defense and cellular resilience during long-term oxidative challenge, consistent with observations that NRF2 signaling remains constitutively active in smoking-associated squamous carcinomas 29,30

Over time, this can even result in chronic obstructive pulmonary disease (COPD), a progressive condition that makes it increasingly difficult to breathe

So, when people smoke frequently, this effect happens over and over throughout the day

15 February 2017