Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-MMAE Size:25mg is highly sensitive

is highly sensitive

PEG3 linker enhances water solubility and provides spatial separation to minimize steric hindrance during binding interactions

134 Purity (HPLC) >= 95% Solubility DMSO

Wolstenholme

targeted delivery in preclinical ADC discovery and optimization workflows

Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-MMAE Size:25mg is highly sensitiveSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG6 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly