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In a large longitudinal study of 1441 people with type 1 diabetes (T1D) in the Diabetes Control and Complications trial (DCCT), intensive insulin treatment reduced the risk of developing DPN by 60%, but a multifactorial approach, including managing hypertension, obesity, and hypertriglyceridemia, is necessary for those with type 2 diabetes (T2D) because of the diseases heterogeneous nature [41]

[DOI] [PMC free article] [PubMed] [Google Scholar] 133.Heckmann BL, Zhang X, Saarinen AM, Liu J

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