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doi: 10.1126/science.291.5505.881 168 RudrappaTCzymmekKJParePWBaisHP

In addition, the enhancement of FAO can be mediated by G protein-coupled bile acid receptor TGR5 agonists and accompanied by an increase in mitochondrial superoxide dismutase 2 (SOD2) activity, which reduces oxidative stress and lipid accumulation in the podocytes thereby attenuating the DKD injury [70]

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Nonetheless, western blot analysis revealed a dose-dependent increase in their protein levels in both 8505C and Hth-7 cells upon KU-57788 treatment (Fig