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Where PDA works primarily through VEGFR2 and nitric oxide pathways, GHK-Cu works through copper-dependent enzyme activation and gene regulation

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Similarly, at 428.202(c)(4), we proposed that for a subsequently approved drug for which there are no quarters during the first calendar year beginning after the drug's first marketed date for which AMP has been reported under section 1927(b)(3) of the Act, the payment amount benchmark period would be the first calendar year in which such drug has at least 1 quarter of AMP reported

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however, we do not believe it is appropriate to apply a specialty attribution exclusion to the Rheumatoid Arthritis episode-based measure for all ophthalmologists, optometrists, and dermatologists