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References 1 World Health Organization (WHO)

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In particular, back in 1996 Przedborski and colleagues indicated that GSH peroxidase activity is reduced in a specific brain region affected in ALS, the precentral gyrus, suggesting that the observed deficit could be involved in the oxidative damage observed in sporadic ALS [102]

This is not likely to represent significant overdose, as B12 is well tolerated by the great majority of people even in very high concentrations (as indeed are most water soluble vitamins)

Red flags you should not ignore Difficulty swallowing (dysphagia): If food feels like it is getting stuck or you have trouble swallowing liquids, this could indicate esophageal narrowing from chronic acid exposure

Always let it run down the side of the vial