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Furthermore, a different approach using intragastrically administered rotenone (5 mg/Kg) in mice showed that the accumulation and aggregation of -synuclein in neurons of the dorsal motor nucleus of the vagus (DMV) and the intermediolateral nucleus (IML) in the spinal cord was accompanied by the selective loss of dopaminergic neurons and astrogliosis, suggesting that the gastric administration of rotenone through the connection of the enteric nervous system (ENS) with anatomical structures of the CNS also induces PD-like features [11,19]

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SCENIC+ infers transcription factor activity and identifies potential corresponding candidate enhancer regions and regulated genes network (eRegulons) 24 , and we applied it on our sn multiomic data

Taken in 1950 the photograph shows Jerne standing at the back by the window with James Watson sitting in front him, an American geneticist who in 1953 helped decipher the molecular structure of deoxyribonucleic acid (DNA)

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