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J Cancer Res Ther (2012) 8(2):2926

ROS damages mitochondrial membrane integrity and mt-DNA, resulting in mitochondrial dysfunction

Several neurodegenerative disorders are associated with critical metabolic impairments including diminished glucose uptake and utilization, as well as hampered mitochondrial activity, with a subsequent decrease in ATP production even preceding the presentation of major pathophysiological phenotypes and symptoms [3, 8,9,10,11]