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"Physiological regulation of the human growth hormone (GH)insulin-like growth factor type I (IGF-I) axis: predominance of pulsatile GH secretion and role of IGF-I feedback." Endocr Rev

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Interestingly, another mechanism was proposed as an alternative way to stabilize NRF2 through the interaction between the autophagy adaptor protein p62/sequestosome-1 (p62/SQSTM1) and KEAP1, which leads to the sequestration of KEAP1 in the autophagy-deficient cells and enables NRF2 accumulation [20]

Additionally, the nuclear export signal (NES) in KEAP1 has been shown to be important for NRF2 regulation, as it was found to facilitate the transport of the NRF2-KEAP1 complex out of the nucleus, which terminates NRF2-mediated antioxidant signaling after stress [16]

21 CampagnoliC.BigliaN.PerisC.SismondiP

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