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Based on the known role of insulin/IGF-I as inhibitors of Tau phosphorylation by inhibiting a major Tau kinase, such as glycogen synthase kinase-, numerous observations demonstrated that IGF-I controls the levels of hyperphosphorylated Tau in brain[326, 327]

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USA 90 , 770774 (1993)

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81,82 Aldose reductase activity is significantly and systemically increased with hyperactivation of the sorbitol pathway in diabetes

Both terms describe a purified, nonpyrogenic, preservative-free aqueous preparation used to dissolve or dilute injectable medications