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Given the lack of strict oversight on the contents of these products, regulatory bodies like the FDA must implement more rigorous controls to protect this vulnerable population

While traditional methods such as randomization, matching, and stratification remain effective for controlling confounding, newer techniques like latent variable modeling with negative controls and machine learning methods such as LASSO, Ridge regression, and random forests offer enhanced flexibility and adaptability

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This does cause a small form of asphyxiation that many smokers become used to and crave