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Supercritical fluid chromatographymass spectrometry: Recent evolution and current trends

Numerous studies have demonstrated that in T2DM patients, plasma GPX4 levels are reduced, whereas ACSL4, MDH, 4-HNE, and ROS levels are significantly elevated, indicating a strong link between oxidative stress in DM and ferroptosis [59,60,61,62]

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Additionally, erythrocytes utilize the reactions of the PPP to generate large amounts of NADPH used in the reduction of glutathione (see below)

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These findings strongly suggest that even though glycine is a nonessential amino acid that can be synthesized from other substrates, the amounts of glycine provided by some common diets is limiting for the synthesis of glutathione