Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-MMAE AHPC S)-AHPC-CO-C10-acid Synonyms CAS Number 2357115-09-2

S)-AHPC-CO-C10-acid Synonyms CAS Number 2357115-09-2 Related CAS Molecular Formula C34H50N4O6S Molecular Weight 642

84 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCCO)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

279 SMILES BrCCCCCNC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 90% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

It reacts with thiol compounds such as amino acid

in particular

Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-MMAE AHPC S)-AHPC-CO-C10-acid Synonyms CAS Number 2357115-09-2SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to