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This discussion deals with the simplest case since, in reality, there are counterions in the solution (from salts), which would form a cloud around the charged macromolecule and partially shield the charged particle from the electric field E

Pak K, Chan SL, Mattson MP (2003) Presenilin-1 mutation sensitizes oligodendrocytes to glutamate and amyloid toxicities, and exacerbates white matter damage and memory impairment in mice

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