Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan Size:5mg 1 SMILES ClC1=CC(Cl)=C(C=C1)C(=O)NS(=O)(=O)C1=CC=C(Br)S1 Purity (HPLC)

1 SMILES ClC1=CC(Cl)=C(C=C1)C(=O)NS(=O)(=O)C1=CC=C(Br)S1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

Its fluorescence emission spectrum lies between those of tetramethylrhodamines and X-rhodamines

71 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCO)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

062 Purity (HPLC) >= 95% Solubility DMSO

and relatively pH-insensitive fluorescence

Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan Size:5mg 1 SMILES ClC1=CC(Cl)=C(C=C1)C(=O)NS(=O)(=O)C1=CC=C(Br)S1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Acetyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Acetyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan,