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The design of these nanomedicines aims to induce both autophagy and apoptosis simultaneously, leveraging the interplay between these pathways to effectively eradicate cancer cells

The current 4-week-per-dose-level schedule was specifically designed to minimize GI side effects while reaching therapeutic doses in a reasonable timeframe

Abstract Excessive alcohol consumption increases oxidative stress, leading to alcoholic liver disease

[39] These allergic reaction-like symptoms, which typically occur within 3060 minutes of ingesting alcoholic beverages, do not appear to reflect the operation of classical IgE- or T cell-related allergen-induced reactions but rather are due, at least in large part, to the action of acetaldehyde in stimulating tissues to release histamine, the probable evoker of these symptoms

doi: 10.1016/j.ebiom.2022.104154 22 FernandezRCMooreVMVan RyswykEMVarcoeTJRodgersRJMarchWAet al