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Lancet Diabetes Endocrinol 2022;10:393-406.ArticlePubMed 134

DMARDs , [12]

An introductory chapter: secondary metabolites, in Secondary metabolites-sources and applications

WHO Consultation on Obesity (1997: Geneva, Switzerland), World Health Organization

Two molecules of acetyl-CoA condense to form HMG-CoA, which is then reduced to mevalonate (MVA) by the rate-limiting enzyme HMGCR with NADPH consumption, and subsequently converted to cholesterol in the endoplasmic reticulum via squalene and lanosterolan energy-intensive process requiring ATP and NADPH ( Figure 1 )