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Preclinical studies have shown that cobalamin inhibits glutamate exocytosis, as an excitatory pain neurotransmitter, and when infused intracerebroventricularly, increases GABA cell contents, as an inhibitory pain neurotransmitter [6, 9]

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Physiological changes Beyond performance metrics, researchers have observed several physiological changes in individuals using SLU-PP-332: Increased red blood cell count and hemoglobin levels Enhanced mitochondrial density in muscle tissue Improved fat oxidation rates during submaximal exercise Reduced markers of oxidative stress post-exercise These physiological adaptations align with the proposed mechanisms of action for SLU-PP-332 and provide a biological basis for the observed improvements in endurance

This is because the deficiency is interlinked with cognitive decline essentially indicating that when your body becomes deficient and lacking in vitamin B12, it can lead to shrinkage of your brain and a decline in brain function