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Ferroptosis and necroptosis thus form a self-amplifying, reciprocal loop mediated by ROS, RIPK3, and lipid peroxidation in ocular diseases, with RIPK3 serving as the molecular intersection (146)

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To address this clinical need, we developed an assay to screen molecular libraries to identify novel hits that can inhibit the specific binding between Munc13-4 and STX7, two modulators of endolysosomal function necessary for eTLR activation

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Candidates are SLC30A10 or Mn binding proteins [120]

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