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doi:10.1021/acschemneuro.3c00717

Tsc2 + / + MEFs ( Tsc1 / vs

TAMs are well-known parts of breast cancer microenvironment and most TAMs within TME are closely related to the M2-like phenotype, which participate in almost all metastatic processes, including local invasion, blood vessel intravasation, extravasation at distant sites and metastatic cell growth (287, 288).The hypoxic areas in tumors are related to the accumulation of macrophages, which assist tumor progression by producing angiogenic factors, mitogenic factors and cytokines related to tumor metastasis (289291)

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Agmatine supplements (e.g., agmatine sulfate) have been the focus of many studies in recent years due to its multifunctional properties